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WE WANT A BABY…For about thirty years since the moment the first child was born "from a test-tube", public attention has been paid to IVP (In vitro production). The basis of these technologies for giving life is unconditionally IVF/ET (In vitro fertilization & embryo transfer).
A child, without any doubt doesn`t come "from a test-tube". The first crucial stages like fertilization and the beginning of development take place in a special incubator.
The IVF method enables one to receive several female sexual cells, fertilize them by spermatozoids outside the body and after a few days of cultivation to transfer them into the uterus of the patient. With this treatment the probability of pregnancy is equal to 40% or more.
Today difficulties in conceiving a child affect one in every 4 couples, half of these are cases due to a disorder in the female reproductive system, but men are almost "catching up" with women. The quality of sperm has been more than halved in the last 50 years.
It is considered that if the desired pregnancy does not happen within a year, it is necessary to consult a doctor.
The destiny of the family in many ways depends on the person whom the spouses refer their problems. Fortunately the modern level of medical development enables us to overcome almost all kinds of sterility. Our experts have studied the experience of leading IVF-centers and methods tested by time. We offer our patients really the best.
Thanks to the reproductive technologies in skilful hands, pregnancy becomes reality even in "the most hopeless cases"."Dnepr IVF" is a Gynecological Clinic. IVF is only a part of services, rendered to patients. Our mastery of all gynecological methods profitably distinguishes us from simple reproductive centers and enables us to achieve pregnancy not only in a natural cycle but also with the help of "artificial fertilization".
The main feature of our work is the absence of big crowds of people. Thanks to this the control of the main stages is very thorough and individual. Our doctors can spare each family couple much more time and ensure more qualified performance of all treatment stages .
Besides we believe that the comfort of the patient` in many ways influences the results.
It goes without a question that a stay in the Dnepr IVF Clinic is handled with the utmost confidentiality which, naturally, most of our clients require.Briefly about the main stages of the IVF method (program "Test-tube children")EXAMINATION OF PATIENTS
It`s a very important stage, which should necessarily be carried out at our base. It helps to make a detailed assessment of the features of the reproductive system of the spouses. It maximally enhances an effective treatment by the IVF method and leads to the desired pregnancy.
INDUCTION OF OVULATION
Each month only one oocyte matures in a woman. The probability of pregnancy in a healthy family couple in a natural cycle is on average 25%. We emphasize - healthy. Patients undergoing treatment by the IVF method take special medicines, which help to receive 5-10 times more oocytes. Hence the probability of pregnancy increases by 1.5 - 2 times.
OOCYTE RETRIEVAL
It is carried out with general anesthesia under ultrasound control for 5-7 minutes. Manipulation takes place as fast and comfortable as possible for the patient. After the puncture the woman stays for 1.5-2 hours under observation and then is usually discharged.
FERTILIZATION AND CULTIVATION
Special incubators ensure all conditions for successful cultivation (growing) of human cells outside the body. In the incubator the "meeting" of oocyte with spermatozoids, and further development of obtained fetuses take place. All manipulations with them are carried out quickly but with utmost care. The cultivation stage may last 48-120 hours.
TRANSFER OF EMBRYOS INTO UTERUS
Usually it`s an absolutely harmless manipulation in which the best of the obtained embryos are introduced into the uterus cavity. For several hours the woman stays under observation, she calms down, and adjusts to the necessary psychological wave. For in the future it will depend on her mood whether her organism accepts new life or not.
Embryos of good quality can be frozen for unlimited time. In the future if the present attempt still fails to provide good results, embryos are unfrozen and transferred into the uterus months and even years later..
SUPPORT OF THE SECOND PHASE OF THE CYCLE
The woman has to spend the next 2-2.5 weeks in a condition of physical, emotional and sexual rest, to perform doctor`s prescriptions for the support of endometrium, taking progesterone, estrogen and other medicines. Even with changes of general state or manifestation of unusual symptoms she must not stop taking the medicines without consulting a doctor.
DIAGNOSTICS OF PREGNANCY
At the time, appointed by the doctor, BIOCHEMICAL PREGNANCY tests can be carried out. The most informative method is the method of quantity determination of contents of chorion gonadotropic hormone (CGH) in blood and some time later - determination of fertile ovum by ultrasound (approximately 5 weeks after transfer). Premature application of often unreliable methods of urine testing may both disappoint and even terrify.Results of treatment in our clinicThe reproductive system of a person is too complex to be compared with repairing of even most complex equipment. Therefore the probability of success in every separately taken couple can be discussed by taking into consideration indexes of health condition, private and world experience.
In an average year 40% of our patients manage to conceive. And that happens in families where conceiving was almost or completely impossible. Some of them have results from their first attempt, others - from their second or third. Some were previously treated in other clinics or had more cycles of the IVF. We can record only current statistics. The probability of pregnancy from three attempts is above 90 percent. Each family couple may have their own chance, determined by dozens of various factors including some inaccessible to analysis. Among them we specify - the age of the woman, the duration of the sterility period, the moral and psychological climate in the family.
The prices of the IVF cycles in our Clinic are on average the same as in any other serious IVF center in Ukraine .
We work with the same equipment, medicines, culture mediums as the whole world.
Nevertheless, the price of treatment in our Clinic costs a patient 2-2.5 times less than in Germany and 4-6 times less than in the USA yet bringing equal results.
Many foreign citizens come directly to us for help taking into account not only the price but also the level of comfort.
…According to recent research carried out in France, the IQ of children "from a test-tube" is notably above the average level. But that is certainly not the result of our manipulations. Most likely it is connected with our patients - they are the people who do their utmost to optimize fertilization, pregnancy and child development. Observing the results of our work we can state: these are the most loving parents in the world.Methods of assisted reproductionIVF, ICSI, IUI (intra-uterus insemination) - ways of overcoming sterility. These technologies previously named as artificial fertilization should in reality be differently named. Their bases are reproduction of natural processes and even a minute deviation from a natural plan in such a complex process leads to failure.
IVF / ET - in vitro fertilization & embryo transfer. Program "Test-tube children" enables us to receive descendents in spite of the most difficult forms of sterility. The obtained embryos are cultivated for several days and then are transferred into the patient`s uterus. The chances of giving birth to a healthy child from the first attempt even with the most "hopeless" forms of sterility at present are 35-45%. Usually we recommend planning 3-4 attempts. With such an approach the cumulative effect reaches 90%.
ICSI - Intracytoplasmic Sperm Injection - injection of spermatozoid into the cytoplasm of the oocyte - it is a type of the IVF method. It is applied for family couples with lowered indexes of mobility and general maintenance of spermatozoids. If conceiving by the classical IVF method is impossible micro-manipulation is carried out where single sperms are induced inside each obtained mature oocyte.
Sometimes fertilization doesn`t happen despite the fact that both spermatozoids and the oocyte are normal. Such difficulties appear due to structural features of the external oocyte membrane when it becomes impermeable for spermatozoids. The ICSI solves this problem as well.
IUI - intra-uterus insemination is a method more or less close to natural fertilization. It offers introduction of the processed sperm into the cervix uteri or the uterus. The necessary conditions for carrying out this method are: passable uterine ducts and favorable indexes of husband`s spermogram. Unfortunately the effectiveness of this method around the world is only about 15 %. With absence of pregnancy it is necessary to refer to the IVF/ET method.
The program of insemination by donor`s sperm allows us to solve the problem of sterility in families with complete lack of husband`s spermatozoids, with several genetic disorders and for single women. The effectiveness of this method according to our observations is much higher than by the IUI husband`s sperm and reaches 20-25% due to a high fertilization ability of the donor sperm.
It should be noted that the decision to carry out ICSI procedure can be made only after a detailed consultation with a doctor- geneticist and after receiving the results of special examination - screening for men. Screening includes receiving chromosome set (caryotype) and molecular observation of Y-chromosome at DNA level. Besides it is necessary to exclude the bearing of several spread mutations leading to mucoviscidosis. All these measures are intended to prevent the transfer of hereditary negative information and to make the correct selection of methods of assisted reproduction. The complete results of this examination are usually ready 7-8 weeks after drawing samples of the patient`s blood.
Specialists and experts were very much worried about possible negative consequences of ICSI application. However, at the moment with skilled organization of work the increase of the level of genetic disorders and other problems has not been found.
The program of DONATIONS OF OOCYTES differs from the conventional IVF method by the usage of the oocytes of women-donors who have high reproductive idexes. Donor oocytes, fertilized by the spermatozoids of the husband are carried into the wife`s uterus cavity who with the fortunate outcome becomes the social and juridical mother of a long-desired child born by her.
The program of SURROGATE maternity can be applied in different ways, in cases when the genetic mother cannot carry the fetus for any reasons. For instance with serious uterus traumas or absence of the uterus.When for solving the problem sexual cells are required…(a little about donor programs)
Of over 300 thousand oocytes present in the ovaries of a mature woman throughout her life only several are used. Others are ejected from the body together with endometrium layer each lunar month.
Earlier donors of oocytes were looked for among relatives of sterile patients but today experts agreed in favor of selection of professional donors that significantly increases results of sterility treatment and enables one to avoid numerous ethical problems.
Firstly, as a rule, women-relatives do not possess those high reproductive abilities which are typical for the donor, chosen on a competitive base.
Secondly, let`s say that the patient`s own sister is for sure also the carrier of not completely expressed family genetic problems.
Besides with distribution of roles between the donor and the recipient (one woman gives egg cells and the other prepares to accept embryos into the uterus) the chances for success rise.
The woman - anonymous donor performs her noble and materially supported mission and the woman-recipient does not get into an ambiguous situation with the biological, social and juridical status of the future child. This mystery is known only to the doctor who carries out fertilization "in vitro". A child belongs only to spouses who asked for help and became initiators of this procedure for overcoming sterility. They carry all the parental duties towards their child.
Donor oocytes are used in cases of deficient function of ovaries including conditions of premature meno-pause, carrying of defective genes, disgenesis of gonads and so on. Besides becoming pregnant for women over 40 is quite difficult but thanks to the application of donor oocytes completely normal children are born by women even in condition of meno-pause.About surrogate maternity. Patients suffering from inability to bear a child or even having no uterus could not even dream of having a genetic child of their own before. Today there are tested working methods and healthy children are in the hands of happy parents.
Embryos are fetuses capable of development in favorable conditions of the uterus of any healthy woman. The method of surrogate maternity is based on this phenomenon, when a child is carried by another woman. Sometimes a close relative of the patient or even her mother can be this woman. More often - it is a woman who becomes in effect a close friend and gets a big financial reward. The best option is cooperation with a woman for whom the state of pregnancy is natural and enjoyable. She can carry out her mission; help another woman guided not only by financial stimulus.
Women - oocyte donors and potential surrogate mothers undergo preliminary examination including gynecological examination, ultrasound, hormone status; latent infections and many other negative factors are excluded. Applicants must have children and be irreproachable in moral and ethical ways. Modern genetic examinations of donors are also carried out: the chromosome set is examined, the carrying of the most widespread hereditary diseases is excluded.
In some countries (for example in Germany and Israel) donation of sexual cells is not carried out, thus creating what is called reproductive tourism.
Today hundreds of sterile family couples from Europe arrive with hope in Ukraine, which has always been the world`s reserve of beauty and "breed". Many of them (practically each third couple) take away something more than just impressions. |
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